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The Nikkei 225 index closed at 39,881.10 points in early trading, up 1.29%.The next "explosion point" of biomedicine may appear in Shenzhen. "China's pharmaceutical innovation ranks first in the second echelon in the world in terms of the quantitative indicators of R&D pipelines and listed new drugs." A few days ago, Song Ruilin, executive president of China Pharmaceutical Innovation Promotion Association, held the "Star of the Bay Area" biomedical source innovation conference in Shenzhen, and believed that China's pharmaceutical research and industrial development were entering a new stage of innovation. Chen Qiyu, vice president of China Pharmaceutical Innovation Promotion Association and executive director and co-CEO of Fosun International, said that Shenzhen has great advantages and development momentum in linking Greater Bay Area's urban development and AI technology. By leveraging the resources in the Bay Area and making good use of these advantages, it is possible to find a new fulcrum in the future biomedical R&D innovation track, and the next "explosion point" of biomedicine is likely to appear in Shenzhen.The Chinese representative called for promoting the political process in Yemen and stressed respect for sovereignty and peace. On the 11th local time, the UN Security Council held a meeting on the situation in Yemen. In his speech, the Chinese representative called on all parties to the Yemen conflict to take practical actions and jointly promote the political process of resolving the Yemen issue. Geng Shuang, China's deputy permanent representative to the United Nations, said that Israel and Houthi forces have been attacking each other, and Israel recently said it would consider launching a new large-scale attack on Yemen, which is deeply worrying. At the same time, the recent dramatic changes in the situation in Syria have brought new unstable factors to the whole Middle East, and the situation in Yemen and the Red Sea may also suffer new shocks. China once again calls on Houthi armed forces to stop harassing merchant ships of various countries in the Red Sea waters and maintain the safety of the navigation channels in the Red Sea waters. At the same time, it calls on all parties concerned to maintain calm and restraint and stop actions that aggravate tensions. (CCTV News)

The yield spread of US 10-year Treasury bonds relative to China's has widened to about 250 basis points, the largest in 22 years.Many places have started issuing coupons to help the consumption of catering and cultural tourism. With the arrival of the peak consumption season at the end of the year, Beijing, Changzhou, Jiangsu, Xi 'an and other places have started a new round of issuing coupons to support the consumption fields such as catering and cultural tourism. Shanghai "Lepin Shanghai" food and beverage coupons were distributed in the first batch in the third round, and all four coupons were arranged at a 30% discount. The first round of 40 million food and beverage coupons were collected within 15 minutes. Consumer vouchers cover many fields and are distributed in rolling stages to meet the needs of different consumers. The data shows that the role of consumer vouchers in stimulating consumption has steadily increased, effectively boosting consumer confidence and driving the recovery of related industries. Experts believe that consumer vouchers can produce a multiplier effect and promote economic activities. At the same time, it is necessary to strengthen supervision, prevent violations, introduce social capital to participate in the issuance of consumer vouchers, and form a diversified development model. (Securities Times)An earthquake with a magnitude of 5.6 occurred in the sea area northeast of Fiji. According to the measurement of the European and Mediterranean Earthquake Center, at 13: 51 local time on December 12th, a magnitude of 5.6 earthquake occurred in the sea area 478 kilometers northeast of Suva, Fiji (15.201 degrees south latitude and 178.282 degrees west longitude) with a focal depth of 10 kilometers.

Backbone Technology: The holding subsidiary recently signed a strategic cooperation agreement on intelligent robots. Backbone Technology (002779) said on the interactive platform on December 12 that recently, Jiangsu Jianmi, the holding subsidiary of the company, signed strategic cooperation agreements with Dongsheng Zhilian and Nanjing Ji Rong respectively, working together to develop and apply automation, visualization and intelligent robots, and promoting the application and development of intelligent technologies in a wider range of fields. Jiangsu Jianmi's Lingrui P1 quadruped robot dog can be used for industrial park management, fire control and public security, daily inspection of power grid and electric power, and inspection of special operation scenes such as smelting enterprises and hazardous chemicals.Hang Seng Science and Technology Index rose to 1%, while Kewang shares rose, with Billie Billie (09626.HK) rising by over 4%, Baidu (09888.HK) rising by 2.8%, Aauto Quicker (01024.HK), Tencent Holdings (00700.HK) rising by 1.8% and Alibaba (09988.HK) rising by over 1%.Green debt base continues to attract gold! Since the beginning of this year, the issuance scale has approached 44 billion yuan. On December 12th, HSBC Jintrust Fund announced that HSBC Jintrust Green Bond Fund was formally established, with the initial raising scale of 5.98 billion yuan. In the first half of this year, the public offering market has issued four green debt bases-Manulife China Bond Green inclusive finance Preferred Index, Oriental China Bond Green Inclusive Theme Financial Preferred Index, Guofu China Bond Green inclusive finance Index and Jiashi China Bond Green Inclusive Theme Financial Preferred Index. Wind data shows that the total issuance scale of these four products reached 31.963 billion yuan, which set off a small climax of debt-based issuance at that time. So far, the issuance scale of green debt base has approached 44 billion yuan during the year. It can be expected that more green debt bases will meet with investors in the future. (CSI Taurus)